Mr. R Gazvani, MD, FRCOG

Consultant Gynaecologist

Subspecialist in Reproductive Medicine and Surgery

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Telephone +44 (0)800 689 1317

Telephone +44 (0)7860 439346

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Intralipids

How do the intralipids work?

Some types of infertility may be caused by a slightly overactive immune system. When this occurs the immune system can attack egg, sperm, embryo and even a developing fetus. This can result in difficulty achieving pregnancy, maintaining the pregnancy, or repeated miscarriages.

Natural killer (NK) cells are regulated by the immune system. In women who have autoimmune issues, the NK cells can react abnormally to an implanting embryo, treating it as an invading cell and signalling for the body to attack it.

Intralipidshave been shown to lower the activity of the NK cells component of our immune system. Studies have found that intralipids can help to regulate the NK cells, allowing the embryo to implant on the uterine wall and grow normally. New research has suggested that women who have experienced recurrent miscarriages or multiple failed IUI or IVF cycles as a result of NK cell activation may benefit from the use of intralipids.

 

Intralipids therapy during IVF treatment

Intralipids have a suppressive action on certain components of the mother's immune system, essentially safeguarding the embryo from the immune reactions which might otherwise result in implantation failure.

Worldwide there is less clinical experience with Intralipids than with IVIG, but we have studied their use in our practice, and have found that our patients have enjoyed great success. Many women who have suffered multiple IVF treatment/implantation failures and who are unable to afford more expensive treatment options turn to Intralipids therapy.

Evidence from both animal and human studies suggest that intralipids administered intravenously may enhance implantation. We advocate aggressive treatment of immunologic implantation dysfunction in women undergoing IVF treatment. In cases where there has been NK cell activation we recommend the use of intralipids to down regulate (deactivate) the NK cells. So far, many women who otherwise might not have achieved success with IVF have gone from infertility to family.

About a year ago, we began evaluating the effect of Intralipid in patients who had activated Natural Killer cells, and for whom IVIG therapy would otherwise be indicated. Thus far we have treated more than 30 women with raised NK cell count in the lining of their womb (endometrium) using Intralipid 20%. More than 60% of the patients achieved viable ongoing pregnancies, showing Intralipid therapy to be at least as effective (and perhaps even more so) than IVIG. There were no significant side effects and patient tolerance of this treatment was high. We anticipate that patients receiving Intralipid will soon start reporting on their experience using Intralipid, on various discussion boards.

 

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Fertility Clinics

Liverpool Fertility Clinic
Spire Murrayfield Hospital
Holmwood Drive
Wirral. CH61 1AU

 

 

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No10 Harley Street
London. W1G 9PF

What People Say!

Natural Killer Cells

Mr R Gazvani Consultant Gynaecologist Natural Killer Cells

Natural Killer Cells are a type of lymphocyte – an immune cell – normally circulating in blood. They make up a large part of the immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. They kill those cells by apoptosis (cell shrinkage)... 

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What is Menopause?

Mr R Gazvani MD FRCOG Consultant Menopause

The menopause is the brief time when a woman’s reproductive life comes to an end. The ovaries stop producing eggs, the hormone “oestrogen” is no longer secreted and the menstrual periods end.

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Recurrent IVF Failure

Mr R Gazvani Consultant Gynaecologist IVF Failure

For many couples experiencing infertility. IVF constitutes the last resort treatment, sometimes after other treatment options have also failed. In general, the underlying cause for IVF failure can be attributed to problems with the embryos, the uterine environment...

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What is Endometriosis?

Mr R Gazvani MD FRCOG Consultant Endometriosis

Endometriosis is a very common condition where cells of the lining of the womb (the endometrium) are found elsewhere, usually in the pelvis and around the womb, ovaries and fallopian tubes.

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What Is Infertility ?

Mr R Gazvani Consultant Gynaecologist What Is Infertility

If a couple is infertile, this means that they have been unable to conceive a child after 12 months of regular sexual intercourse without birth control. Primary infertility means they have never had a child.. Secondary infertility means that the infertile person has had one or more children in the past...

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Assisted Conception

Mr R Gazvani MD FRCOG Consultant Conception

Gynaecologist Mr Gazvani specialist in infertility and assisted conception treatment and pre-implantation genetic diagnosis.

Assisted Conception falls into three main areas.

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